A 12-year-old who weighs 200 pounds has been on a diet and exercise program for the past 6 months. His or her weight has not changed. Other vital signs include blood pressure 130/70 mm Hg, pulse 80, and respiratory rate (RR) 20 at rest. Family history does not include severe issues with cholesterol at young ages. A paternal uncle had a myocardial infarction last year at age 42. Both grandfathers died from strokes prior to age 65. The lipid profile shows low-density lipoprotein 200 and high-density lipoprotein 40. The mother wants “pills” to control the lipid levels.
- Are statins given to children?
- Would the gender of the patient make a difference?
- How would you approach obtaining information on the prior lifestyle management plan?
- How would you classify this patient in terms of cardiac risk?
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Pharm Case Study 39 Hyperlipidemia
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Pharm Case Study 39 Hyperlipidemia
Hyperlipidemia, an elevation of plasma lipids, can be attributed to genetic defects or secondary factors such as diet, or drugs. According to (Sharma, Kumar & Mishra, 2014) the majority of cholesterol in humans is manufactured endogenously. However, its synthesis is regulated by the 3-hydroxy-3-methylglutaryl coenzyme (HMG CoA), which provides a basis for pharmacologic therapy. The elevation of plasma lipids can be managed through dietary modifications and exercise. However, in case the patient does not respond like the one provided in the case study, pharmacological therapy is recommended. The recommended pharmacological therapy is the use of statins.
Whether Statins Are Given To Children
Children who have severe hyperlipidemia and who may not respond to dietary modifications as is the case provided are recommended to undergo pharmacological therapy. In such a case, statis are recommended. According to (Perry, Hockenberry, Lowdermilk & Wilson, 2013) statins treatment is recommended for children aged >8 years with low density lipoprotein cholesterol (LDL) greater than 190mg/dL. The authors assert that statins are more effective compared to other drugs and have the ability of raising the high density lipoprotein cholesterol (HDL).
The Impact of Gender of the Patient
Women have generally lower body mass index, with increased adipose tissue and smaller organs. According to (Mombelli et al., 2015) this are likely to impact on the pharmacokinetic profile through the increase in the volume of distribution of lipophilic drugs. Several research studies have found that women and men achieve different target goals when they undergo statins treatment in the management of hyperlipidemia. The authors point that thoug…………………………………………………………………………………………………
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