Categories
Writers Solution

Identify the patient’s symptoms and the available demographic and historical data

Neurological Disorders Case Study [WLOs: 1, 2] [CLOs: 1, 2]

Prior to beginning work on this discussion forum, read Chapter 15 of your course text.

For this discussion, you will pick one of the cases listed in the Week 5 Discussion – Case Studies  Download Week 5 Discussion – Case Studiesdocument, and take on the role of the clinician.

In your initial post,

  • Identify the patient’s symptoms and the available demographic and historical data.
  • Discuss your differential diagnosis and provide a thorough basis for any diagnoses you have included.
  • Determine what (if any) additional testing you would order and how this would be helpful in clarifying the diagnosis.
  • Finally, explain recommendations for the patient/family for ongoing functioning (social, occupational and academic, if applicable).

You must use a minimum of two peer-reviewed articles in your discussion to support your diagnostic conclusions.

To assist you with your research consider using the library’s Scholarly, Peer-Reviewed, and Other Credible Sources (Links to an external site.) tip sheet.

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Categories
Writers Solution

correct for self-reporting bias and to estimate state- specific and demographic subgroup–specific trends and projections of the preva- lence of categories of body-mass index (BMI)

T h e n e w e n g l a n d j o u r n a l o f m e d i c i n e

n engl j med 381;25 nejm.org December 19, 20192440

From the Center for Health Decision Sci- ence (Z.J.W.) and the Departments of Health Policy and Management (S.N.B.) and Social and Behavioral Sciences (A.L.C., J.L.B., C.M.G., C.F., S.L.G.), Harvard T.H. Chan School of Public Health, Boston; and the Department of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, D.C. (M.W.L.). Address reprint requests to Mr. Ward at the Center for Health Decision Science, Harvard T.H. Chan School of Public Health, 718 Huntington Ave., Boston, MA, 02115, or at zward@ hsph . harvard . edu.

N Engl J Med 2019;381:2440-50. DOI: 10.1056/NEJMsa1909301 Copyright © 2019 Massachusetts Medical Society.

BACKGROUND Although the national obesity epidemic has been well documented, less is known about obesity at the U.S. state level. Current estimates are based on body measures reported by persons themselves that underestimate the prevalence of obesity, es- pecially severe obesity.

METHODS We developed methods to correct for self-reporting bias and to estimate state- specific and demographic subgroup–specific trends and projections of the preva- lence of categories of body-mass index (BMI). BMI data reported by 6,264,226 adults (18 years of age or older) who participated in the Behavioral Risk Factor Surveillance System Survey (1993–1994 and 1999–2016) were obtained and cor- rected for quantile-specific self-reporting bias with the use of measured data from 57,131 adults who participated in the National Health and Nutrition Examination Survey. We fitted multinomial regressions for each state and subgroup to estimate the prevalence of four BMI categories from 1990 through 2030: underweight or normal weight (BMI [the weight in kilograms divided by the square of the height in meters], <25), overweight (25 to <30), moderate obesity (30 to <35), and severe obesity (≥35). We evaluated the accuracy of our approach using data from 1990 through 2010 to predict 2016 outcomes.

RESULTS The findings from our approach suggest with high predictive accuracy that by 2030 nearly 1 in 2 adults will have obesity (48.9%; 95% confidence interval [CI], 47.7 to 50.1), and the prevalence will be higher than 50% in 29 states and not below 35% in any state. Nearly 1 in 4 adults is projected to have severe obesity by 2030 (24.2%; 95% CI, 22.9 to 25.5), and the prevalence will be higher than 25% in 25 states. We predict that, nationally, severe obesity is likely to become the most common BMI category among women (27.6%; 95% CI, 26.1 to 29.2), non- Hispanic black adults (31.7%; 95% CI, 29.9 to 33.4), and low-income adults (31.7%; 95% CI, 30.2 to 33.2).

CONCLUSIONS Our analysis indicates that the prevalence of adult obesity and severe obesity will continue to increase nationwide, with large disparities across states and demo- graphic subgroups. (Funded by the JPB Foundation.)

A B S T R A C T

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

Zachary J. Ward, M.P.H., Sara N. Bleich, Ph.D., Angie L. Cradock, Sc.D., Jessica L. Barrett, M.P.H., Catherine M. Giles, M.P.H., Chasmine Flax, M.P.H.,

Michael W. Long, Sc.D., and Steven L. Gortmaker, Ph.D.

Special Article

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Projec ted Pr e va lence of Obesit y a nd Se v er e Obesit y

Although the growing obesity epi-demic in the United States has been well documented,1-4 less is known about long- term trends and the future of obesity prevalence. Although national projections of obesity have been made previously,5-7 state-specific analyses are limited. State-specific projections of the bur- den of obesity are important for policymakers, given the considerable variation in the prevalence of obesity across states,8 the substantial state- level financial implications,9 and the opportunity for obesity-prevention interventions to be imple- mented at a local level.10-13

However, a barrier to accurate state-level pro- jections is the paucity of objectively measured body-mass index (BMI) data according to state. The Behavioral Risk Factor Surveillance System (BRFSS), a nationally representative telephone survey of more than 400,000 adults each year,14 provides participants’ estimates of height and weight according to state. These data have been used to track obesity prevalence and are the basis of maps that have illustrated the growth of the obesity epidemic.1 Although the BRFSS pro- vides valuable state-level estimates over time, the reliance on subjective body measures reported by participants substantially underestimates the prev- alence of obesity owing to the well-documented self-reporting bias.8,15,16 We developed a method of bias correction to adjust the entire distribu- tion of BMI in the BRFSS surveys from 1993 through 2016 and estimated state-level historical trends and projections of the prevalence of BMI categories from 1990 through 2030 according to demographic subgroup.

M e t h o d s

Overview

We adjusted reported BMI data from the BRFSS to align the data with objectively measured BMI distributions from the National Health and Nu- trition Examination Survey (NHANES), a nation- ally representative survey in which measured data on height and weight are collected with the use of standardized examination procedures.17 We estimated trends in the prevalence of BMI categories according to subgroup in each state and made projections through 2030. The first author designed the study, gathered and analyzed

the data, and vouches for the accuracy and com- pleteness of the data. All the authors critically revised the manuscript and made the decision to submit the manuscript for publication.

Data

We obtained BRFSS data from 1993 through 1994 and 1999 through 2016, periods during which annual data were collected for all 50 states and Washington, D.C. (except for Wyoming in 1993, Rhode Island in 1994, and Hawaii in 2004). We obtained nationally representative NHANES data from 1991 through 1994 (phase 2 of NHANES III) and from 1999 through 2016 (con- tinuous NHANES). Data from pre-1999 BRFSS surveys were restricted to 1993 and 1994 to co- incide with phase 2 of NHANES III. (Before 1993, not all states were included in the BRFSS.) We cleaned each data set to ensure that the vari- ables of interest were not missing and ensured that reported height and weight in the BRFSS were biologically plausible. Our final BRFSS data set included 6,264,226 adults (18 years of age or older), and our NHANES data set included 57,131 adults. (Exclusion criteria and respondent characteristics are provided in Section 1 in the Supplementary Appendix, available with the full text of this article at NEJM.org.)

Adjustment for Self-Reporting Bias

We adjusted reported BMI data from the BRFSS so that the distribution was similar to measured BMI from NHANES. Because both the BRFSS and NHANES are designed to be nationally repre- sentative surveys, data from NHANES can be used to adjust participant-reported body measures in the BRFSS. By adjusting the entire distribution of reported BMI to be consistent with measured BMI in NHANES, we adjusted for self-reporting bias while preserving the relative position of each person’s BMI.8 Specifically, we estimated the dif- ference between participant-reported BMI and measured BMI according to quantile and then fit cubic splines to smoothly estimate self-reporting bias across the entire BMI distribution. Each per- son’s BMI was then adjusted for this bias given his or her BMI quantile. We adjusted BMI dis- tributions separately according to sex and time period (1993–1994, 1999–2004, 2005–2010, and 2011–2016) to control for potential time trends

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in self-reporting bias and composition of demo- graphic subgroups. (Additional details are provid- ed in Section 2 in the Supplementary Appendix.)

State-Specific Trends and Projections

BMI categories were defined according to the Centers for Disease Control and Prevention (CDC) guidelines: underweight or normal weight (BMI [the weight in kilograms divided by the square of the height in meters], <25), overweight (25 to <30), moderate obesity (30 to <35), and severe obesity (≥35).18 We used multinomial (renormal- ized logistic) regressions to predict the preva- lence of each BMI category as a function of time. This method ensures that the prevalence of all categories sums to 100% in each year and allows estimation of nonlinear trends in the prevalence of BMI categories. Our reduced covariate model (i.e., with year as the independent variable) im- plicitly accounts for trends in the composition of demographic subgroups (e.g., age distribution and composition of race or ethnic group catego- ries) within each state, since the relative contri- butions of these various factors (and their po- tential changing effect over time) are already reflected in the prevalence estimates. Such an ap- proach also implicitly controls for trends in other variables that may affect BMI, such as smoking or illness. Although it is important to explicitly con- trol for these variables when estimating the ef- fect of BMI on related health outcomes, because our outcome of interest was the prevalence of BMI categories over time, it was not necessary to control for these variables because their effect was already reflected in the observed prevalence estimates used to fit the models. (Additional de- tails and a discussion of previous approaches are provided in Sections 3.1 and 3.2 in the Supple- mentary Appendix.)

Regressions were performed nationally and for each state independently, while taking the complex survey structure of the BRFSS into ac- count. We estimated historical trends and pro- jections of the prevalence of each BMI category from 1990 through 2030, as well as the preva- lence of overall obesity (BMI, ≥30). We also made projections for demographic subgroups to examine trends and explore the effect of geogra- phy (i.e., state of residence) on obesity trends within subgroups. We estimated trends accord- ing to sex (male or female), race or ethnic group

(non-Hispanic white, non-Hispanic black, His- panic, or non-Hispanic other), annual house- hold income (<$20,000, $20,000 to <$50,000, or ≥$50,000), education (less than high-school grad- uate, high-school graduate to some college, or college graduate), and age group (18 to 39, 40 to 64, or ≥65 years) (Section 3.3 in the Supplemen- tary Appendix). Because of the small sample sizes and changing BRFSS categories of race or ethnic group over time, we combined five groups (“American Indian or Alaskan Native,” “Asian,” “Native Hawaiian or Pacific Islander,” “other,” and “multiracial”) into one “non-Hispanic other” category.

In accordance with the CDC guidelines that consider BRFSS estimates unreliable if they are based on a sample of fewer than 50 people,19 we suppressed state-level estimates from subgroups with fewer than 1000 respondents; given our data set of 20 rounds of BRFSS surveys, we sup- pressed estimates from subgroups with fewer than 50 respondents on average per year in a state. Thus, estimates for the following sub- groups were suppressed: non-Hispanic black adults in 12 states (Alaska, Hawaii, Idaho, Maine, Montana, New Hampshire, North Dakota, Ore- gon, South Dakota, Utah, Vermont, and Wyo- ming) and Hispanic adults in 2 states (North Dakota and West Virginia).

To account for uncertainty, we bootstrapped both data sets (NHANES and BRFSS) 1000 times, considering the complex structure of each survey (Section 3.4 in the Supplementary Ap- pendix) and repeated all analyses (i.e., adjustment for self-reporting bias and state-specific projec- tions). We report the mean and 95% confidence interval (calculated as the 2.5 and 97.5 percen- tiles of the bootstrapped values) for all esti- mates.

Assessment of Predictive Accuracy and Sensitivity Analyses

To evaluate the accuracy of our approach, we restricted our data sets (NHANES and BRFSS) to include only data from 1999 through 2010. We then repeated our analyses with this subset of data and predicted the prevalence of each BMI category in 2016 (i.e., 6 years after the last ob- served year in our truncated data). We compared our predictions with the observed prevalence (corrected for self-reporting bias) in 2016. This

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Projec ted Pr e va lence of Obesit y a nd Se v er e Obesit y

exercise allowed us to evaluate the accuracy of our approach in predicting future values and allowed us to assess the potential effect of the change in the BRFSS sample design in 2011 to include cell-phone interviews on our estimation of trends. For our predictions, we calculated the coverage probability (i.e., the percentage of ob- served estimates that fell within our 95% confi- dence intervals), the percentage of our mean predictions that fell within a certain distance (e.g., 10% relative error) of the observed esti- mate, and the mean absolute error.

In a sensitivity analysis, we also made projec- tions based on self-reported body measures (i.e., no adjustment for self-reporting bias). Statistical analyses were performed with the use of R soft- ware, version 3.2.5 (R Foundation for Statistical Computing), with BRFSS bootstrapping per- formed in Java for computational efficiency.

R e s u l t s

Bias-Corrected BMI Data

After we corrected for self-reporting bias, our adjusted BMI distributions in the BRFSS data set did not differ significantly (P>0.05) from those in the NHANES data set for each sex and time period. Adjustment of the entire BMI distribu- tion also ensured that the prevalence of each BMI category in the BRFSS data set was similar to that in the NHANES data set. BMI values for men and women were adjusted on average by 0.71 and 1.76 units, respectively, with differential (increasing) adjustment according to reported BMI. (Additional details are provided in Sec- tion 2 in the Supplementary Appendix.)

Predictive Accuracy

Our coverage probability (i.e., the percentage of time that our 95% confidence intervals con- tained the observed estimate) for state-level prev- alence in 2016 was 94.6% across the four BMI categories. Subgroup-specific coverage probabil- ities were 92.5% on average (Section 4 in the Supplementary Appendix). Our mean predictions for states were within 10% (relative error) of the reported estimate 95.6% of the time, with a mean absolute error of 0.85 percentage points. Although our coverage probabilities are high, our mean predictions are less accurate for subgroups with smaller sample sizes.

Trends and Projections

Our projections show that the national preva- lence of adult obesity and severe obesity will rise to 48.9% (95% confidence interval [CI], 47.7 to 50.1) and 24.2% (95% CI, 22.9 to 25.5), respec- tively, by 2030, with large variation across states. Maps of state-level prevalence of obesity and severe obesity over time are provided in Figure 1. Based on current trends, our projections show that the prevalence of overall obesity (BMI, ≥30) will rise above 50% in 29 states by 2030 and will not be below 35% in any state. We also project that the prevalence of severe obesity (BMI, ≥35) will rise above 25% in 25 states (Table 1). State- level trends in the prevalence of each BMI cate- gory are presented according to subgroup in Section 5 in the Supplementary Appendix. These trends show that the prevalence of overweight is declining as obesity develops in more people.

Our sensitivity analyses, which did not cor- rect for self-reporting bias, revealed similar trends over time but with an overall projected obesity prevalence that was on average 5.3 percentage points lower than the bias-corrected obesity prevalence (relative error of approximately 10%) and similar underestimates according to sub- group (Section 6 in the Supplementary Appendix).

Our projections also revealed large disparities in obesity prevalence across subgroups. We project that by 2030 severe obesity will be the most com- mon BMI category nationwide among women, black non-Hispanic adults, and low-income adults (i.e., household income <$50,000) (Fig. 2).

In addition, we found large geographic dis- parities within subgroups (Fig. 3). (State-level maps and tables are provided in Sections 7 and 8 in the Supplementary Appendix.) In general, we found a higher prevalence of obesity among non- Hispanic black and Hispanic adults than among non-Hispanic white adults, and the heterogene- ity in the composition of the non-Hispanic other category of race or ethnic group across states was ref lected by the variation in obesity preva- lence across states for this group.

We also found a large gradient in the preva- lence of obesity according to income. For exam- ple, our projections show that severe obesity will be the most common BMI category in 44 states among adults with an annual household income of less than $20,000, as compared with only 1 state among adults with an annual household income

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T h e n e w e n g l a n d j o u r n a l o f m e d i c i n e

B Prevalence of Severe Obesity (BMI, ≥35)A Prevalence of Overall Obesity (BMI, ≥30) 1990 1990

2000 2000

2010 2010

2020 2020

2030 2030

0 10 20 30 40 50 60

Prevalence (%)

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Projec ted Pr e va lence of Obesit y a nd Se v er e Obesit y

of greater than $50,000 (Fig. 3). State-specific analyses according to subgroup are provided in Sections 7 through 9 in the Supplementary Ap- pendix, including the results for education and age subgroups, as well as suppressed estimates for race or ethnic groups.

D i s c u s s i o n

In this study, we used more than 20 years of data from more than 6 million adults and applied an analytical approach that provided more accurate state-level estimates of BMI trends, corrected for self-reporting bias. Our method differentially ad- justed the entire BMI distribution, an approach that preserves heterogeneity, in contrast to regres- sion-based approaches that adjust mean values.6,15 Adjustment of the entire BMI distribution has been shown to better capture the tails of the BMI distribution, resulting in more accurate es- timates of obesity prevalence, especially for severe obesity.8

Although analyses of trends in adult obesity in the United States have been performed previ- ously,1-6,15,20-23 a strength of our analysis is that we provided both national and state-level, sub- group-specific estimates (i.e., 832 demographic subgroups) based on bias-corrected data from more than 6 million adults over many years. Although previous criticisms of obesity projec- tions — often based on small samples over short periods — argue that changes in obesity preva- lence have not followed a predictable pattern,24 we observed remarkably stable and predictable trends across a wide range of states and demo- graphic subgroups. Moreover, we provided em- pirical evidence of the predictive validity of our approach, showing that our model has a high degree of accuracy. Our coverage probabilities of approximately 95% indicate that our 95% confi-

dence intervals appropriately reflect the uncer- tainty around our estimates.

Our sensitivity analyses, which did not adjust for self-reporting bias, revealed similar trends to those in our main analysis but with a lower prevalence, as expected. For example, our unad- justed projections of the prevalence of obesity among women in 2030 were on average 13% (6.4 percentage points) lower than our bias- corrected projections, a finding that highlights the importance of correcting for self-reporting bias to obtain accurate prevalence estimates.

We found that nearly 1 in 2 adults nationwide will probably have obesity by 2030, with large disparities across states and demographic sub- groups. Using our model, we projected that by 2030 the majority of adults in 29 states will have obesity and that the prevalence of obesity will approach 60% in some states and not be below 35% in any state. These results are similar to previous estimates showing that 57% of children 2 to 19 years of age in 2016 are projected to have obesity by the age of 35 years.7

We noted that as more adults cross the threshold to obesity, the prevalence of overweight is declining, a finding that highlights the impor- tance of assessing changes in weight across the entire BMI distribution rather than focusing on only one category. Especially worrisome is the projected rise in the prevalence of severe obesity, which is associated with even higher mortality and morbidity25 and health care costs.9 Using our model, we projected that by 2030 nearly 1 in 4 U.S. adults will have severe obesity, and the prevalence will be higher than 25% in 25 states. Severe obesity is thus poised to become as preva- lent as overall obesity was in the 1990s. Indeed, our projections suggest that severe obesity may become the most common BMI category among adults in 10 states by 2030 and even more common in some subgroups, especially among women, non-Hispanic black adults, and low-income adults; these findings highlight persistent disparities according to sex, race or ethnic group, and in- come. The high projected prevalence of severe obesity among low-income adults and the high medical costs of severe obesity have substantial implications for future health care costs,9 espe- cially as states expand access to obesity-related services for adult Medicaid beneficiaries.26

Although severe obesity was once a rare con-

Figure 1 (facing page). Estimated Prevalence of Overall Obesity and Severe Obesity in Each State, from 1990 through 2030.

Shown is the estimated prevalence of overall obesity (Panel A) and severe obesity (Panel B) among adults in each U.S. state from 1990 through 2030. Overall obesity includes the BMI (body-mass index) categories of moderate obesity (BMI, 30 to <35) and severe obesity (BMI, ≥35).

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T h e n e w e n g l a n d j o u r n a l o f m e d i c i n e

State Overall Obesity (BMI, ≥30)* Severe Obesity (BMI, ≥35)

Overall Men Women Overall Men Women

percentage (95% confidence interval)

U.S. overall 48.9 (47.7–50.1) 48.2 (46.8–49.6) 49.9 (48.5–51.4) 24.2 (22.9–25.5) 21.1 (19.6–22.6) 27.6 (26.1–29.2)

Alabama 58.2 (56.2–60.2) 56.7 (53.8–59.4) 59.7 (57.3–62.3) 30.6 (28.5–32.8) 25.6 (22.6–28.5) 35.7 (33.2–38.3)

Alaska 49.3 (46.3–52.2) 48.9 (45.0–53.1) 50.0 (46.1–54.1) 24.2 (21.4–26.8) 21.7 (17.5–25.7) 27.6 (24.1–31.4)

Arizona 51.4 (48.9–53.9) 49.3 (45.7–53.0) 53.6 (50.5–56.6) 24.4 (22.1–26.7) 20.8 (17.5–24.2) 28.3 (25.3–31.2)

Arkansas 58.2 (55.7–60.4) 56.7 (53.2–59.9) 59.9 (57.0–62.8) 32.6 (30.1–35.1) 29.6 (26.2–33.1) 36.1 (33.0–39.1)

California 41.5 (39.9–43.3) 41.1 (39.0–43.4) 42.1 (40.0–44.3) 18.3 (16.8–19.8) 16.1 (14.1–18.1) 20.9 (19.0–22.8)

Colorado 38.2 (36.3–40.3) 37.5 (34.8–40.0) 39.2 (36.7–42.0) 16.8 (15.2–18.6) 14.3 (12.1–16.6) 19.8 (17.6–22.2)

Connecticut 46.6 (44.4–48.9) 46.5 (43.5–49.4) 46.9 (44.3–49.6) 22.5 (20.6–24.6) 19.8 (17.2–22.7) 25.3 (22.9–27.9)

Delaware 53.2 (51.0–55.7) 51.4 (48.2–55.0) 55.0 (51.9–58.1) 27.1 (24.8–29.6) 22.2 (19.0–25.6) 31.7 (28.7–34.8)

District of Columbia 35.3 (33.0–37.8) 32.3 (29.1–36.3) 39.0 (35.9–42.2) 17.3 (15.2–19.3) 11.3 (8.9–13.9) 23.1 (20.3–26.1)

Florida 47.0 (45.0–48.9) 47.9 (45.5–50.2) 46.3 (43.9–48.8) 21.3 (19.7–23.1) 19.0 (16.7–21.1) 24.0 (22.0–26.3)

Georgia 51.9 (49.9–54.2) 49.6 (46.6–52.7) 54.5 (51.8–57.2) 26.6 (24.3–28.8) 21.2 (18.3–24.2) 32.1 (29.6–34.7)

Hawaii 41.3 (39.2–43.4) 43.3 (40.3–46.1) 39.1 (36.4–41.9) 18.2 (16.4–20.2) 17.5 (14.9–20.1) 19.1 (17.0–21.7)

Idaho 47.7 (45.4–50.0) 48.0 (44.5–51.3) 47.7 (44.6–50.6) 23.0 (20.8–25.2) 20.8 (17.9–23.8) 26.0 (23.3–28.7)

Illinois 50.0 (47.8–52.1) 48.6 (45.3–51.3) 51.6 (48.9–54.5) 25.5 (23.5–27.7) 20.7 (17.8–23.5) 30.4 (27.5–33.0)

Indiana 51.6 (49.7–53.6) 50.7 (48.1–53.5) 52.9 (50.3–55.4) 26.9 (24.8–29.0) 24.1 (21.2–26.9) 30.3 (27.8–32.8)

Iowa 52.0 (50.0–54.0) 52.6 (49.8–55.2) 51.9 (49.2–54.4) 26.4 (24.4–28.5) 24.8 (22.0–27.7) 28.8 (26.1–31.5)

Kansas 55.6 (53.8–57.5) 54.3 (51.8–56.9) 57.0 (54.7–59.5) 30.6 (28.7–32.5) 26.7 (24.3–29.3) 34.8 (32.6–37.2)

Kentucky 54.8 (52.9–56.8) 54.5 (51.8–57.2) 55.4 (53.0–57.9) 29.4 (27.4–31.4) 26.0 (23.3–28.8) 33.1 (30.5–35.7)

Louisiana 57.2 (55.1–59.2) 56.3 (53.2–59.3) 58.3 (55.6–61.0) 31.2 (28.9–33.5) 26.8 (23.5–29.9) 36.0 (33.2–38.9)

Maine 50.3 (48.1–52.6) 49.4 (46.3–52.5) 51.3 (48.5–54.0) 24.2 (22.1–26.4) 20.9 (18.2–23.7) 27.7 (25.0–30.3)

Maryland 50.0 (48.1–52.0) 48.0 (45.4–50.8) 52.1 (49.7–54.5) 24.6 (22.8–26.6) 19.7 (17.5–22.1) 29.4 (27.0–31.9)

Massachusetts 42.3 (40.2–44.3) 43.1 (40.4–45.7) 41.7 (39.1–44.2) 20.0 (18.2–22.1) 18.7 (16.3–21.4) 21.5 (19.3–24.0)

Michigan 51.9 (50.2–53.7) 51.2 (48.8–53.6) 53.0 (50.8–55.2) 27.2 (25.5–29.1) 24.4 (21.9–26.9) 30.7 (28.3–33.1)

Minnesota 46.1 (44.3–48.0) 48.2 (46.0–50.4) 44.3 (41.9–46.6) 20.4 (18.7–22.2) 20.0 (17.7–22.3) 21.6 (19.5–23.6)

Mississippi 58.2 (56.0–60.2) 54.3 (51.1–57.2) 62.0 (59.3–64.6) 31.7 (29.5–33.9) 24.6 (21.4–28.0) 38.6 (35.9–41.2)

Missouri 52.4 (50.2–54.6) 51.0 (47.8–54.1) 53.9 (51.0–56.5) 28.3 (26.1–30.5) 24.4 (21.5–27.5) 32.4 (29.6–35.1)

Montana 44.2 (41.8–46.6) 44.5 (41.4–47.6) 44.3 (41.3–47.5) 21.4 (19.3–23.5) 19.6 (16.7–22.6) 23.9 (21.2–26.8)

Nebraska 51.3 (49.3–53.3) 51.0 (48.3–53.7) 51.7 (49.2–54.1) 25.4 (23.4–27.4) 21.5 (18.9–24.1) 29.6 (27.0–32.2)

Nevada 45.5 (42.7–48.3) 45.3 (41.5–49.0) 45.8 (42.1–49.6) 20.6 (18.1–23.4) 18.1 (14.7–22.1) 23.4 (20.0–26.8)

New Hampshire 48.8 (46.6–51.1) 50.5 (47.3–53.5) 47.1 (44.1–50.0) 24.1 (21.9–26.5) 21.9 (18.8–25.2) 26.6 (23.7–29.6)

New Jersey 46.6 (44.4–48.6) 48.6 (45.6–51.6) 44.8 (42.0–47.4) 21.7 (19.8–23.5) 19.9 (17.2–22.7) 23.8 (21.4–26.2)

New Mexico 51.8 (49.5–54.1) 49.5 (46.0–52.6) 54.6 (51.8–57.3) 24.8 (22.6–27.0) 22.7 (19.6–26.0) 27.5 (24.9–30.3)

New York 42.8 (41.0–44.8) 42.0 (39.5–44.7) 43.9 (41.4–46.3) 19.8 (18.2–21.6) 17.5 (15.2–19.9) 22.5 (20.4–24.8)

North Carolina 50.3 (48.3–52.2) 47.3 (44.8–49.9) 53.4 (50.8–55.7) 25.7 (23.6–27.5) 21.0 (18.3–23.6) 30.6 (28.0–33.0)

North Dakota 53.9 (51.6–56.1) 56.5 (53.4–59.4) 51.3 (48.5–54.0) 26.9 (24.7–29.0) 26.6 (23.4–29.6) 27.9 (24.9–30.7)

Ohio 53.2 (51.0–55.3) 52.4 (49.5–55.3) 54.1 (51.3–56.9) 26.8 (24.8–28.8) 23.8 (21.1–26.6) 30.0 (27.2–32.7)

Oklahoma 58.4 (56.4–60.2) 59.5 (56.9–61.9) 57.5 (54.9–59.8) 31.7 (29.7–33.9) 29.0 (26.1–32.0) 34.9 (32.6–37.6)

Oregon 47.5 (45.5–49.5) 47.9 (45.1–50.8) 47.3 (44.7–49.8) 24.1 (22.0–26.1) 21.6 (18.7–24.5) 27.1 (24.5–29.7)

Pennsylvania 50.2 (48.2–52.1) 50.8 (48.1–53.2) 50.0 (47.7–52.5) 24.8 (22.7–26.8) 23.3 (20.7–25.8) 27.0 (24.5–29.6)

Table 1. Projected State-Specific Prevalence of Adult Obesity and Severe Obesity in 2030.

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Projec ted Pr e va lence of Obesit y a nd Se v er e Obesit y

State Overall Obesity (BMI, ≥30)* Severe Obesity (BMI, ≥35)

Overall Men Women Overall Men Women

percentage (95% confidence interval)

Rhode Island 47.3 (45.0–49.9) 48.8 (45.3–52.3) 46.3 (42.8–49.7) 22.9 (20.6–25.4) 21.9 (18.7–25.3) 24.5 (21.6–27.6)

South Carolina 52.8 (51.0–54.6) 49.6 (47.0–52.3) 56.0 (53.6–58.3) 27.2 (25.3–29.1) 21.2 (18.8–23.8) 33.0 (30.7–35.4)

South Dakota 50.6 (48.1–52.9) 53.0 (49.6–56.1) 48.2 (45.1–51.4) 25.2 (22.9–27.7) 24.1 (20.8–27.3) 26.9 (24.1–29.9)

Tennessee 55.8 (53.9–57.8) 55.0 (52.1–57.8) 56.9 (54.4–59.5) 29.9 (27.8–32.1) 26.5 (23.5–29.7) 33.7 (31.2–36.5)

Texas 52.9 (50.9–54.7) 50.1 (47.3–52.5) 55.9 (53.5–58.5) 26.6 (24.6–28.5) 22.5 (20.0–25.2) 31.1 (28.5–33.8)

Utah 43.2 (41.3–45.1) 43.9 (41.5–46.3) 42.7 (40.2–45.2) 20.6 (18.9–22.6) 18.8 (16.7–21.3) 23.0 (20.6–25.5)

Vermont 43.6 (41.5–45.8) 43.1 (40.2–46.1) 44.2 (41.7–47.0) 20.7 (18.9–22.7) 17.8 (15.4–20.2) 23.9 (21.5–26.4)

Virginia 48.9 (46.7–50.9) 46.0 (43.0–48.9) 51.8 (48.9–54.7) 25.3 (23.3–27.5) 20.7 (18.0–23.4) 30.0 (27.4–32.4)

Washington 47.4 (45.6–49.2) 48.0 (45.7–50.3) 47.2 (44.9–49.5) 22.6 (20.9–24.4) 20.9 (18.6–23.2) 25.0 (23.0–27.2)

West Virginia 57.5 (55.6–59.4) 57.0 (54.2–59.6) 58.3 (55.8–61.0) 30.8 (28.7–32.8) 27.0 (24.1–29.9) 35.2 (32.5–37.9)

Wisconsin 50.3 (48.0–52.7) 50.3 (47.0–53.2) 50.7 (47.6–53.7) 25.5 (23.4–27.8) 23.1 (20.2–26.1) 28.6 (25.7–31.7)

Wyoming 48.2 (45.6–50.9) 45.5 (41.6–49.3) 51.3 (47.7–54.8) 22.4 (19.8–25.0) 19.2 (16.0–22.4) 26.1 (22.7–29.8)

* “Overall obesity” includes the body-mass index (BMI) categories of moderate obesity (BMI, 30 to <35) and severe obesity (BMI, ≥35).

Table 1. (Continued.)

Figure 2. Projected National Prevalence of BMI Categories in 2030, According to Demographic Subgroup.

Shown is the projected national prevalence of BMI categories in 2030, according to sex, race or ethnic group, and annual household income.

0 10 20 30 40 50 60 70 80 90 100

Prevalence (%)

Underweight or normal weight (BMI, <25)

Overweight (BMI, 25 to <30)

Moderate obesity (BMI, 30 to <35)

Severe obesity (BMI, ≥35)

Overall

Male

Female

Non-Hispanic white

Non-Hispanic black

Hispanic

Non-Hispanic other

<$20,000

$20,000 to <$50,000

≥$50,000

Annual Household Income

Race or Ethnic Group

Sex

21.5 (20.5−22.6)

17.9 (17.1−18.8)

19.8 (18.9−20.7)

37.9 (35.9−39.8)

17.1 (16.0−18.2)

17.5 (16.6−18.6)

21.7 (20.8−22.6)

23.5 (22.4−24.6)

19.4 (18.5−20.3)

21.4 (20.6−22.3)

31.4 (30.2−32.6)

27.7 (26.7−28.8)

24.6 (23.6−25.7)

31.7 (30.0−33.6)

30.5 (29.0−32.0)

25.6 (24.3−26.9)

30.2 (29.1−31.2)

26.6 (25.7−27.5)

32.5 (31.2−33.8)

29.7 (28.6−30.7)

25.6 (24.6−26.6)

25.8 (24.8−26.7)

23.9 (22.8−24.9)

16.8 (15.5−18.1)

27.9 (26.4−29.4)

25.2 (24.0−26.5)

24.7 (23.8−25.5)

22.3 (21.6−23.0)

27.1 (25.7−28.5)

24.8 (23.9−25.6)

21.5 (20.2−22.9)

28.6 (27.1−30.0)

31.7 (30.2−33.2)

13.7 (12.4−15.0)

24.5 (22.8−26.2)

31.7 (29.9−33.4)

23.4 (22.1−24.8)

27.6 (26.1−29.2)

21.1 (19.6−22.6)

24.2 (22.9−25.5)

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T h e n e w e n g l a n d j o u r n a l o f m e d i c i n e

A Sex

B Race or Ethnic Group

C Annual Household Income

Male Female

Non-Hispanic White Non-Hispanic Black

Hispanic Non-Hispanic Other

<$20,000 $20,000 to <$50,000

≥$50,000 Overall

Underweight or normal weight (BMI, <25)

Overweight (BMI, 25 to <30)

Moderate obesity (BMI, 30 to <35)

Severe obesity (BMI, ≥35)

Suppressed estimate

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Projec ted Pr e va lence of Obesit y a nd Se v er e Obesit y

dition, our findings suggest that it will soon be the most common BMI category in the patient populations of many health care providers. Given that health professionals are often poorly pre- pared to treat obesity,27 this impending burden of severe obesity and associated medical compli- cations has implications for medical practice and education. In addition to the profound health effects, such as increased rates of chronic dis- ease and negative consequences on life expec- tancy,25,28 the effect of weight stigma29 may have far-reaching implications for socioeconomic dis- parities as severe obesity becomes the most common BMI category among low-income adults in nearly every state.

Given the difficulty in achieving and main- taining meaningful weight loss,30,31 these find- ings highlight the importance of prevention ef- forts. Although some cost-effective prevention interventions have been identified,10 a range of sustained approaches to maintain a healthy weight over the life course, including policy and envi- ronmental interventions at the community level that address upstream social and cultural deter- minants of obesity,32 will probably be needed to prevent further weight gain across the BMI dis- tribution.

Our analysis has certain limitations. Although we found that our model predictions are accu- rate for states overall, our point estimates (i.e., mean predictions) may be less accurate for sub- groups with smaller sample sizes. However, our high coverage probabilities for all subgroups

indicate that we appropriately accounted for the uncertainty around our estimates, which high- lights the importance of considering the 95% confidence intervals of our projections as well. In addition, our assessment of predictive accu- racy reveals that our projections are robust to the change in the BRFSS sample design in 2011 to include cell-phone interviews. Although our predictive validity checks from 2010 through 2016 help build confidence in our approach, projec- tions through 2030 involve a much longer period, so the uncertainty around our projections may be larger than estimated because we assumed that current trends will continue.

Because of data limitations, we could not ex- plore trends in obesity according to all race or ethnic groups included in our “non-Hispanic other” category. We found large differences in the prevalence of obesity across states for this category, a finding that is consistent with the well-known differences in obesity prevalence among Native American, Native Hawaiian, and Asian populations that are included in this hetero- geneous category, which differs in composition from state to state. Also, because the BRFSS re- ports categories of annual household income (as opposed to actual dollar values), we were unable to adjust the household income of respondents for inflation over time.

Finally, because of the small sample size, we combined underweight (BMI, <18.5) and normal weight into one category. (Underweight com- prises only 2% of respondents in our NHANES data set.) Although this grouping may be prob- lematic when used as the reference category for estimating BMI-related health risks, it should not present any problems for estimating the prevalence of BMI categories.

We project that given current trends, nearly 1 in 2 U.S. adults will have obesity by 2030, and the prevalence will be higher than 50% in 29 states and not below 35% in any state — a level currently considered high. Furthermore, our pro- jections show that severe obesity will affect nearly 1 in 4 adults by 2030 and become the most common BMI category among women, black non- Hispanic adults, and low-income adults.

Supported by the JPB Foundation. Disclosure forms provided by the authors are available with

the full text of this article at NEJM.org.

Figure 3 (facing page). Projected Most Common BMI Category in 2030 in Each State, According to Demo- graphic Subgroup.

Shown is the projected most common BMI category (underweight or normal weight, overweight, moderate obesity, or severe obesity) in 2030 in each U.S. state, according to sex (Panel A), race or ethnic group (Panel B), and annual household income (Panel C). In accordance with the Centers for Disease Control and Prevention guidelines that consider Behavioral Risk Factor Surveil- lance System (BRFSS) survey estimates unreliable if they are based on a sample of fewer than 50 respon- dents,19 we suppressed state-level estimates from sub- groups with fewer than 1000 respondents; given our data set of 20 rounds of BRFSS surveys, we suppressed estimates from subgroups with fewer than 50 respon- dents on average per year in a state.

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Projec ted Pr e va lence of Obesit y a nd Se v er e Obesit y

References 1. Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The spread of the obesity epidemic in the United States, 1991-1998. JAMA 1999; 282: 1519-22. 2. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014; 311: 806-14. 3. Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in obe- sity among adults in the United States, 2005 to 2014. JAMA 2016; 315: 2284-91. 4. Hales CM, Fryar CD, Carroll MD, Freedman DS, Ogden CL. Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007-2008 to 2015-2016. JAMA 2018; 319: 1723-5. 5. Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and eco- nomic burden of the projected obesity trends in the USA and the UK. Lancet 2011; 378: 815-25. 6. Finkelstein EA, Khavjou OA, Thomp- son H, et al. Obesity and severe obesity forecasts through 2030. Am J Prev Med 2012; 42: 563-70. 7. Ward ZJ, Long MW, Resch SC, Giles CM, Cradock AL, Gortmaker SL. Simula- tion of growth trajectories of childhood obesity into adulthood. N Engl J Med 2017; 377: 2145-53. 8. Ward ZJ, Long MW, Resch SC, et al. Redrawing the US obesity landscape: bias- corrected estimates of state-specific adult obesity prevalence. PLoS One 2016; 11(3): e0150735. 9. Wang YC, Pamplin J, Long MW, Ward ZJ, Gortmaker SL, Andreyeva T. Severe obesity in adults cost state Medicaid pro- grams nearly $8 billion in 2013. Health Aff (Millwood) 2015; 34: 1923-31. 10. Gortmaker SL, Wang YC, Long MW, et al. Three interventions that reduce child- hood obesity are projected to save more than they cost to implement. Health Aff (Millwood) 2015; 34: 1932-9. 11. Roberto CA, Lawman HG, LeVasseur MT, et al. Association of a beverage tax on sugar-sweetened and artificially sweetened beverages with changes in beverage prices

and sales at chain retailers in a large ur- ban setting. JAMA 2019; 321: 1799-810. 12. Silver LD, Ng SW, Ryan-Ibarra S, et al. Changes in prices, sales, consumer spend- ing, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: a before-and- after study. PLoS Med 2017; 14(4): e1002283. 13. State policies to prevent obesity. Prince- ton, NJ: Robert Wood Johnson Founda- tion (https://www .stateofobesity .org/ state – policy/ ). 14. Centers for Disease Control and Pre- vention. Behavioral Risk Factor Surveil- lance System: about BRFSS (https://www .cdc .gov/ brfss/ about/ index .htm). 15. Ezzati M, Martin H, Skjold S, Vander Hoorn S, Murray CJ. Trends in national and state-level obesity in the USA after correction for self-report bias: analysis of health surveys. J R Soc Med 2006; 99: 250-7. 16. Connor Gorber S, Tremblay M, Moher D, Gorber B. A comparison of direct vs. self-report measures for assessing height, weight and body mass index: a systematic review. Obes Rev 2007; 8: 307-26. 17. Centers for Disease Control and Pre- vention. National Health and Nutrition Ex- amination Survey: about NHANES (http:// www .cdc .gov/ nchs/ nhanes/ about_nhanes .htm). 18. Centers for Disease Control and Pre- vention. Overweight & obesity: defining adult obesity (https://www .cdc .gov/ obesity/ adult/ defining .html). 19. Klein RK, Proctor SE, Boudreault MA, Turczyn KM. Healthy People 2010 criteria for data suppression. Healthy People 2020 Stat Notes 2002; 24: 1-12 20. Wang Y, Beydoun MA, Liang L, Cabal- lero B, Kumanyika SK. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 2008; 16: 2323-30. 21. Sturm R, Hattori A. Morbid obesity rates continue to rise rapidly in the United States. Int J Obes (Lond) 2013; 37: 889-91. 22. Preston SH, Stokes A, Mehta NK, Cao B. Projecting the effect of changes in smok- ing and obesity on future life expectancy

in the United States. Demography 2014; 51: 27-49. 23. Hales CM, Fryar CD, Carroll MD, Freedman DS, Aoki Y, Ogden CL. Differ- ences in obesity prevalence by demo- graphic characteristics and urbanization level among adults in the United States, 2013-2016. JAMA 2018; 319: 2419-29. 24. Flegal KM, Ogden CL. Use of projec- tion analyses and obesity trends — reply. JAMA 2016; 316: 1317. 25. The Global BMI Mortality Collabora- tion. Body-mass index and all-cause mor- tality: individual-participant-data meta- analysis of 239 prospective studies in four continents. Lancet 2016; 388: 776-86. 26. Jannah N, Hild J, Gallagher C, Dietz W. Coverage for obesity prevention and treatment services: analysis of Medicaid and state employee health insurance pro- grams. Obesity (Silver Spring) 2018; 26: 1834-40. 27. Dietz WH, Baur LA, Hall K, et al. Management of obesity: improvement of health-care training and systems for pre- vention and care. Lancet 2015; 385: 2521- 33. 28. The GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 2017; 377: 13-27. 29. Puhl RM, Heuer CA. The stigma of obesity: a review and update. Obesity (Sil- ver Spring) 2009; 17: 941-64. 30. Barte JC, ter Bogt NC, Bogers RP, et al. Maintenance of weight loss after lifestyle interventions for overweight and obesity, a systematic review. Obes Rev 2010; 11: 899-906. 31. LeBlanc ES, Patnode CD, Webber EM, Redmond N, Rushkin M, O’Connor EA. Behavioral and pharmacotherapy weight loss interventions to prevent obesity-related morbidity and mortality in adults: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA 2018; 320: 1172-91. 32. Katan MB. Weight-loss diets for the prevention and treatment of obesity. N Engl J Med 2009; 360: 923-5. Copyright © 2019 Massachusetts Medical Society.

specialties and topics at nejm.org Specialty pages at the Journal’s website (NEJM.org) feature articles in cardiology, endocrinology, genetics, infectious disease, nephrology,

pediatrics, and many other medical specialties.

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Demographic trends indicate that a large number of baby boomers are on the verge of retiring.

Marketing is one of the most important aspects within a healthcare organization. In order to create an effective marketing plan, we must be able to identify the right product/service at the right time to the right person and place. Marketing plans begin with the identification of these 4 core principles which we refer to as the “4 Ps”. Together the 4P’s, of product, price, placeandpromotion create a marketing mix and which are interdependent.

INSTRUCTIONS

Using the scenario below, write a recommendation in an APA formatted paper of at least 500 words and in current APA format and is supported by 2 peer-reviewed, scholarly references and 1 instance of Biblical integration.

Demographic trends indicate that a large number of baby boomers are on the verge of retiring. The Bay Area Medical Practice is meeting to focus on the next 5-year strategic plan. It has performed a patient analysis and has determined that 40% of its patient base is composed of baby boomers. From an operational perspective; what would be your recommendation to address the 4 P’s of Marketing?

Length of assignment – 500 words

(Excluding title page/ Cover page and reference page.)

APA Format 

Number of citations:

  • 2 peer-reviewed, scholarly references and 1 instance of Biblical integration.

Acceptable sources 

  • Scholarly articles published within the last five years

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Use of demographic data have on public health initiatives?

Write a 700- to 1,050-word article in which you: Write a 250- to 300-word response to the following questions: What impact does the use of demographic data have on public health initiatives?What type of data do you believe is most valuable for this purpose?  according to APA guidelines.

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Demographic data on public health initiatives

Using demographic data on public health initiatives is important. It ensures optimizing patient outcomes for various populations in that it enhances research about the treatment options and their effects on various populations. For example, calcium channel blockers or thiazide diuretics have been proven to be more effective in treating hypertension among African-Americans than ACE inhibitors (Berg, 2018). Policymakers can hence set guidelines and regulations regarding ethics and diversity management based on evidence from demographic data. 

Further, demographic data enhances equitability in provision of health services. By analyzing the demographic data, patterns regarding underserved communities can be established, leading to suitable public health interventions (NHS Employers, 2019). For example, such data can show that people in a certain geographical location are prone to be smoking or abusing alcohol, leading to substance abuse awareness campaigns in the region.

Demographic data also enables prioritizing of health services. Policymakers are able to determine costs and potential outcomes of various health interventions, consequently prioritizing that which will have the maximum impact (Berg, 2018). For example, more Covid-19 resources can be directed to the elderly population since studies show the disease mostly affects this demography.

Age could be deemed as one of the most valuable demographic data. This is because diagnosis and treatment are always determined by age. Yet diagnosis and treatment are the basis for all health initiatives, public or private. Other valuable demographic data include gender and race. Socio-economic data such as income, employment status and lifestyle are also valuable (NHS Employers, 2019).

Hence there are various types of demographic data that are …………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………….. public health initiatives ……………….

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The Demographic Transition Model (DTM)

You will write a research paper about the demographic transition model and global food production and distribution for a growing human population to meet global food security goals. You must use APA format for the paper and documentation.
Include the following: •Describe the demographic transition model and how it was developed by demographers.•Describe the 4 phases of demographic transition. ◦For each phase, compare crude birth rates (CBR) to crude death rates (CDR), and state whether the population is stable, growing, or declining in each. ·•According to demographers, what factors lead to a decline of the CDR in phase two and the CBR in phase three of the demographic transition? ·•Briefly describe 3 living conditions in developed countries that have reached phase four, and contrast them with these same conditions in developing countries that remain in earlier phases. ◦Note: When comparing and contrasting, include details for each of the entities being compared and contrasted. For example, if comparing availability of clean water in a developed country, contrast availability of clean water in a developing country.•Research and describe a program for developing countries that would help improve 1 of the 3 conditions that you compared.•Food security means that everyone has an adequate amount of nutritious food to lead healthy lives. Research and describe 1 specific program that helps developing countries reach food security goals

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Demographic Transition Model, Global Food Production and Distribution for a Growing Human Population

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The Demographic Transition Model (DTM)

            The demographic transition model (DTM) is a model that explains the changes in population over a period (Bongaarts, 2009). Warren Thomson, an American demographer, developed the model, when he made the demographic interpretations of industrialized countries in 1929. Beginning 1700s owing to developments in the technology and improvements in the agriculture sector, the population changes occurred. Many people lived beyond their adolescents, life expectancy increased with reduction in death rates and increasing birth rates. Demographers noted the differences on population demographics, which were initially the same regardless of geographic location. Consequently, demographers developed the demographic transition model to explain these population changes. The demographic transition model is based on the population trends of two demographic characteristics; the death and birth rates.

The Phases of the Demographic Transition Model (DTM)             The birth and death rat……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………….

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