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Discuss the pharmacokinetics and pharmacodynamics related to anxiolytic medications used to treat GAD

Generalized Anxiety Disorder is a psychological condition that affects 6.1 million Americans, or 3.1% of the US Population. Despite several treatment options, only 43.2% of those suffering from GAD receive treatment. This week you will review several different classes of medication used in the treatment of Generalized Anxiety Disorder. You will examine the potential impacts of pharmacotherapeutics used in the treatment of GAD. Please focus your assignment on FDA approved indications when referring to different medication classes used in the treatment of GAD.

To Prepare
  • Review the Resources for this module and consider the principles of pharmacokinetics and pharmacodynamics.
  • Reflect on your experiences, observations, and/or clinical practices from the last 5 years and think about how pharmacokinetic and pharmacodynamic factors altered his or her anticipated response to a drug.
  • Consider factors that might have influenced the patient’s pharmacokinetic and pharmacodynamic processes, such as genetics (including pharmacogenetics), gender, ethnicity, age, behavior, and/or possible pathophysiological changes due to disease.
  • Think about a personalized plan of care based on these influencing factors and patient history with GAD.

The QUESTION

1.   Discuss the pharmacokinetics and pharmacodynamics related to anxiolytic medications used to treat GAD. 

2.   Compare and contrast different treatment options that can be used

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Medications Used to Treat Mental Illness

You are a nurse at an outpatient clinic and are presented with a 68-year-old female client.  She is experiencing the following symptoms: decreased appetite, disturbed sleep pattern, fatigue, difficulty concentrating, disordered thought process, anhedonia, guilt, and low self-esteem. The doctor diagnoses the client with major depressive disorder.  Answer the following questions:

  • What medication do you think is likely to be prescribed for this client and why? 
  • What are some important teachings you would give this client when administering the first dose? 
  • When following up with the client 2 months later.  What are some changes you may expect to see with the client? If the client is not displaying the expected outcomes, what are some possible alternatives for the client? 
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Quite rightly, we do not normally take the behavior of animals as a model for how we may treat them” (Singer & Mason 773).

  • The q Quite rightly, we do not normally take the behavior of animals as a model for how we may treat them” (Singer & Mason 773).
  1. “Quite rightly, we do not normally take the behavior of animals as a model for how we may treat them” (Singer & Mason 773).   
  2. “A land ethic, then reflects the existence of an ecological conscience, and this in turn reflects a conviction of individual responsibility for the health of the land” (Leopold – The Land Ethic p.124).
  3.  “With consistency, a great soul has simply nothing to do” (Emerson self reliance p.7). 
  4. “Yet he does not know what to do with the time he saves, and spends one part of his income to kill the time he is so proud of having saved” (Fromm 331).
  5. “It is a peculiar sensation, this double-consciousness, this sense of always looking at one’s self through the eyes of others, of measuring one’s soul by the tape of a world that looks on in amused contempt and pity” (Du Bois – Of Our Spiritual Strings p.2).  
  • The Quotes from the book: A world of Ideas
  1. “Let us finally consider how naïve it is altogether to say: ‘Man ought to be such and such’” (Nietzsche – Morality as Anti-Nature p.350).
  2. “It is much safer to be feared than to be loved when one of the two must be lacking” (Machiavelli  – The Qualities of The Prince p.227).
  3. “If you want to govern the people, you must place yourself below them, if you want to lead the people, you must learn how to follow them” (Lao-tzu Thoughts from the Tao-te Ching p.213-214).
  4. “For to be subject to appetite is to be a slave, while to obey the laws laid down by society is to be free” (Rousseau – The Origin of Civil Society p.253).
  5. “As I read and contemplated the subject, behold! that very discontentment which Master Hugh had predicted would follow my learning to read had already come, to torment and sting my soul to unutterable anguish”  (Douglass – From Narrative of The Life p.334)